Total Drug

R. F. Mais, R. D. McCook, Y. T. Oester, Research Service,

Hines V. A. Hospital, Hines, Illinois

The two programs "Fraction Bound" and "Total Drug" provide

for the calculation of fraction drug bound or / total drug

concentration for a given total drug concentration or /

fraction drug bound calculated from the usual protein binding

constants of number of sites N(1) and N(2) and the corresponding

association constants K(1) and K(2) and the protein concen-

tration P. The programs are written in FOCAL for the PDP-

Lab 8E with 4K core. The output is fraction bound (FB) or

total drug (CO), free drug concentration (C), bound drug to

protein ratio (R), R to free drug ratio (R/C), and fraction of

protein sites occupied (FP).